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Scientist I/II, DMPK

South San Francisco, CA 94080

Posted: 11/17/2022 Employment Type: Direct Hire/Perm Job Category: Scientific Job Number: 512561 Country: United States Is job remote?: No

Job Description

PURPOSE OF JOB:         
Salary Range:   120-170K
  • Seeking a talented individual to conduct evaluations of the ADME/PK properties of novel compounds.
  • This Scientist position will have experience in DMPK (in vitro/in vivo) areas and is expected to work/solve problems independently


• Perform in vitro metabolism studies as required and participate in designing in vivo PK studies to support drug discovery

• Understand relationships between in vitro and in vivo ADME

• Identify metabolic hotspots in potential drug candidates

• Proficient in inter-species PK scaling approaches utilizing in vitro/in vivo data sets

• Ensure that the data generated and released are of high quality and present such data to discovery teams leading to decisions and project progressions

  • Collect, analyze, summarize, upload to internal databases and report high quality data in a timely manner

• Identify, trouble-shoot and communicate on possible issues arising during data analysis

• Ability and willingness to mentor junior colleagues in ADME/PK techniques

• Have a good working knowledge of LC-MS/MS and allied analytical techniques to support in vitro studies

• Work with other project team members to facilitate identification of compounds with good DMPK properties.  Teamwork is an essential component.


• PhD in Pharmaceutical Sciences or a related field


• 1 – 5 years of experience in DMPK/ADME in the pharmaceutical industry is desirable.

  • Scientific knowledge of DMPK/ADME. Specific interest/knowledge in small molecule drug discovery
  • Experience developing and running in vitro and/in vivo DMPK assays/studies are essential.
  • Proficiency in preclinical formulation techniques is a plus.
Good written and verbal communication skills
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